Dr. Caroline Cheng

Cheng ZW

Dr. Caroline Cheng. Associate prof. in the department of nephrology and vascular biology UMC Utrecht & associate prof. in the department of cardiology Erasmus MC. Regenerative Vascular Medicine Laboratory, University Medical Center Utrecht Heidelberglaan 100, 34785 CX Utrecht. The Netherlands.

Dr Caroline Cheng Ph.D. trained in medical biology at the VU medical center in Amsterdam in the Netherlands and graduated in 2000. She conducted her PhD research at the Erasmus MC in Rotterdam, studying the effect of hemodynamic factors such shear stress on the pathogenicity of the vascular wall under the supervision of prof. A. van der Steen, prof. R. Krams, dr. R. de Krom and prof. F. Grosveld. She defended her thesis in 2006, after which she worked as a post doc, and as an assistant prof. at the department of cardiology in the molecular cardiology lab of dr. H. Duckers, focusing on mechanisms of vascular biology in normal development and cardiovascular disease. In 2008 and 2009, she received two important starter grants, including the VENI research grant of the KNAW (Dutch Royal Academy of Science), which enabled her to set up her own research line focused on the contribution of perivascular cell types on vascular growth in health and disease.

In 2013, she was awarded with a post-doctoral fellowship by the regenerative medicine institute of the UMC Utrecht, and became associate prof. in both the nephrology department of the UMC Utrecht and the cardiology department of the Erasmus MC. With this additional funding, she expanded her group and started investigating the therapeutic potential of cell-based vascular therapy and the effects of different types of biological extracellular matrix components on the regenerative capacities of mature vascular cells and progenitor cells. In addition, in 2014, she received an important Dutch consolidator grant (VIDI KNAW), which enabled her to further expand her group. She is part of the Dutch Heart Foundation funded Queen of Heart consortium, an international consortium of cardiovascular scientists and clinicians that focusses on the identification of biomarkers of heart disease in women. Within the current funding, her group is set to expand towards 11 FTEs in the beginning of 2016. Current research focusses on vascular biology and includes studies that evaluate the relation between vascular dysfunction and onset of fibrosis in a broad range of diseases, including chronic kidney disease, and heart failure.

Keynote papers:

(1) Cheng C et al. Circulation. 2012 Jun 26;125(25):3142-58;

(2) Cheng C et al. Circ Res. 2011 Aug 5;109(4):382-95;

(3) Larsen K et al. Eur Heart J. 2012 Jan;33(1):120-8;

(4) Cheng C et al. Circ Res. 2010 May 28;106(10):1656-66;

(5) Cheng C et al. Circulation. 2009 Jun 16;119(23):3017-27;

(6) Cheng C et al. J Clin Invest. 2007 Mar;117(3):616-26;

(7) Segers D et al. Circulation. 2007 Feb 6;115(5):609-16;

(8) Cheng C et al. Circulation 2006 114:e615(9);

(9) Cheng C et al. Circulation. 2006 Jun 13;113(23):2744-53;

(10) Cheng C et al. Blood. 2005 Dec 1;106(12):3691-8.